BoneScore® is Powered by Science

A robust body of published clinical literature is available that explores the use of BoneScore® in various scenarios such as treatment, osteoporosis, and bone-related diseases. In literature, BoneScore® is referred to as the Bone Material Strength index, or BMSi, and is powered by the OsteoProbe device.

FDA Clearance

Approved in Europe

Published Clinical Studies

Published Clinical Studies from Top Medical Centers

BoneScore® has been extensively researched in clinical studies at top medical institutions in the US, Europe, and Australia. In the US, clinical studies have been published by researchers at Mayo Clinic, Massachusetts General Hospital, Harvard University, Tufts University, Columbia University, and Johns Hopkins University.

Review Articles

Added Value of Impact Microindentation in the Evaluation of Bone Fragility: A Systematic Review of the Literature

2020, Leiden University Medical Center, Netherlands

Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism

2018, Mayo Clinic, US & Hospital
del Mar, Spain

Clinical experience with microindentation in vivo in humans

2017, Hospital del Mar, Spain

Clinical Measurements of Bone Tissue Mechanical Behavior Using Reference Point Indentation

2018, Washington University
in St. Louis

Intraoperative use of impact microindentation to assess distal radius bone quality

2022, Vanderbilt University Medical Center, Nashville, TN, USA

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Treatments, Intervention & Exercise

Bone Tissue Properties Measurement by Reference Point Indentation in Glucocorticoid-Induced Osteoporosis.

2015, Hospital del Mar, Spain

Bone Density, Microarchitecture, and Tissue Quality After Long-Term Treatment With Tenofovir/Emtricitabine or Abacavir/Lamivudine.

2017, Hospital del Mar, Spain

Bone Density, Microarchitecture, and Tissue Quality Long-term After Kidney Transplant.

2015, Hospital del Mar, Spain

Bone density, microarchitecture, and tissue quality after 1 year of treatment with tenofovir disoproxil fumarate.

2018, Hospital del Mar, Spain

Maintenance low dose systemic glucocorticoids have limited impact on bone strength and mineral density among incident renal allograft recipients: A pilot prospective cohort study.

2018, Hospital del Mar, Spain

High-Impact Mechanical Loading Increases Bone Material Strength in Postmenopausal Women-A 3-Month Intervention Study.

2018, Sahlgrenska University, Sweden

Inflammation status in HIV-positive individuals correlates with changes in bone tissue quality after initiation of ART.

2019, Hospital del Mar, Spain

Changes in bone quality after Roux-en-Y gastric bypass: A prospective cohort study in subjects with and without type 2 diabetes.

2020, University of Oslo, Norway

Treatments of osteoporosis increase bone material strength index in patients with low bone mass

2020, Leiden University Medical Center

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Osteoporosis & Fracture

Bone Material Strength as Measured by Microindentation In Vivo Is Decreased in Patients With Fragility Fractures Independently of Bone Mineral Density.

2015, Leiden University Medical Center, Netherlands

Women with previous stress fractures show reduced bone material strength.

2016, University of Oslo, Norway

Bone material strength is associated with areal BMD but not with prevalent fractures in older women.

2016, Sahlgrenska University, Sweden

Bone material strength index as measured by impact microindentation is low in patients with fractures irrespective of fracture site.

2017, Leiden University Medical Center, Netherlands

Fracture during oral bisphosphonate therapy is associated with deteriorated bone material strength index.

2017, Hospital del Mar, Spain

Reduced Bone Material Strength is Associated with Increased Risk and Severity of Osteoporotic Fractures. An Impact Microindentation Study.

2017, University of Oslo, Norway

Bone Material Strength Index as Measured by Impact Microindentation in Postmenopausal Women With Distal Radius and Hip Fractures.

2018, Harvard University, US & Beth Israel Deaconess Medical Center, US & Massachusetts General Hospital

The Prevalence of Vertebral Fractures Is Associated With Reduced Hip Bone Density and Inferior Peripheral Appendicular Volumetric Bone Density and Structure in Older Women.

2018, Sahlgrenska University, Sweden

Cortical Bone Material Strength Index and Bone Microarchitecture in Postmenopausal Women With Atypical Femoral Fractures.

2019, Harvard University, US & Beth Israel Deaconess Medical Center, US & Massachusetts General Hospital

Associations between bone impact microindentation and clinical risk factors for fracture.

2019, Barwon University, Australia

Bone material strength index is associated with prior fracture in men with and without moderate chronic kidney disease

2020, Barwon University, Australia

Reference Intervals for Bone Impact Microindentation in Healthy Adults: A Multi-Centre International Study

2023, Barwon University, Australia

Bone material strength index as measured by in vivo impact microindentation is normal in subjects with high-energy trauma fractures

2022, Leiden University Medical Center, Netherlands

Associations between bone material strength index and FRAX scores

2021, Barwon University, Australia

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Secondary Osteoporosis, Diseases & Underlying Conditions

In Vivo Assessment of Bone Quality in Postmenopausal Women With Type 2 Diabetes

2014, Mayo Clinic, US

Advanced Glycation Endproducts and Bone Material Strength in Type 2 Diabetes.

2016, Columbia University, US

Type 2 Diabetes Mellitus Is Associated With Better Bone Microarchitecture But Lower Bone Material Strength and Poorer Physical Function in Elderly Women: A Population-Based Study.

2017, Sahlgrenska University, Sweden

Impact microindentation in men with impaired fasting glucose and type 2 diabetes.

2021, Leiden University Medical Center, Netherlands

PTH and bone material strength in hypoparathyroidism as measured by impact microindentation.

2020 , Columbia University, US

Assessment of Bone Health in Patients With Type 1 Gaucher Disease Using Impact Microindentation. Journal of Bone and Mineral Research.

2017, Hospital del Mar, Spain

Discrepancy between bone density and bone material strength index in three siblings with Camurati-Engelmann disease.

2017, Hospital del Mar, Spain

Bone density, microarchitecture, and material strength in chronic kidney disease patients at the time of kidney transplantation.

2017, Hospital del Mar, Spain

The use of microindentation for the study of bone properties in type 1 diabetes mellitus patients.

2020, Hospital del Mar, Spain

Bone tissue quality in patients with monoclonal gammopathy of uncertain significance.

2020, Hospital del Mar, Spain

Bone material strength index is associated with prior fracture in men with and without moderate chronic kidney disease.

2020, Barwon University, Australia

Bone material strength index as measured by impact microindentation is altered in patients with acromegaly.

2017, Leiden University Medical  Center, Netherlands

Bone Material Strength Index as Measured by Impact Microindentation is Low in Patients with Primary Hyperparathyroidism

2021, Leiden University Medical Center, Netherlands

Evidence of impaired bone quality in men with type 1 diabetes: a cross-sectional study

2021, Norwegian University of Science and Technology (NTNU), Trondheim, Norway

Impact microindentation in men with impaired fasting glucose and type 2 diabetes

2021, Deakin University, Geelong, Australia

Clinical description and genetic analysis of a novel familial skeletal dysplasia characterized by high bone mass and lucent bone lesions

2022, Hospital del Mar, Barcelona, Spain

Bone-microarchitecture and bone-strength in a sample of adults with hypophosphatasia and a matched reference population assessed by HR-pQCT and impact microindentation

2022, University of Copenhagen, Copenhagen, Denmark

Update on the pathogenesis and treatment of skeletal fragility in type 2 diabetes mellitus

2021, Mayo Clinic, Rochester, MN, USA

Human tibial cortical bone with high porosity in type 2 diabetes mellitus is accompanied by distinctive bone material properties

2022, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

UKCA black fill

European Union User Manuals

OsteoProbe User Manual (English) – Released March 2023
OsteoProbe User Manual (Italian) – Released March 2023

OsteoProbe User Manual (English) – Released April 19, 2022
OsteoProbe User Manual (English) – Released February 17, 2021
OsteoProbe User Manual (English) – Released January 4, 2021
OsteoProbe User Manual (English) – Released November 12, 2020
OsteoProbe User Manual (English) – Released October 16, 2020
OsteoProbe User Manual (English) – Released January 15, 2020
OsteoProbe User Manual (English) – Released May 31, 2019
OsteoProbe User Manual (English) – Released July 11, 2018
OsteoProbe User Manual (English) – Released January 18, 2018
OsteoProbe User’s Guide (English) – Released August 15, 2017

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BONE SCORE FOR PHYSICIANS

Indication For Use and Safety Information
The OsteoProbe is indicated for use as a measurement tool to measure bone tissue resistance to microindentation on the tibia in adults. The clinical significance of resistance to microindentation is unknown. The device is not intended to diagnose or treat any clinical condition.

Like with any percutaneous procedure, there is a small risk of infection. The sale, distribution, and use of the OsteoProbe are restricted to prescription use. Federal law (United States of America) restricts this device to use by, or on the order of, a physician.

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